Oral bioavailability reveals an overestimation of the toxicity of polycyclic aromatic hydrocarbons in atmospheric particulate matter

Abstract Polycyclic aromatic hydrocarbons (PAHs) in atmospheric particulate matter have adverse effects on human health, yet total PAH concentrations should overestimate the toxicity compared to bioavailable amount of PAHs. To explore this hypothesis, we measured PAHs oral bioavailability vitro with aerodynamic diameter lower than 10 µm (PM ) using a test that mimics digestive system. This assay combines use simulated gastrointestinal fluids and dialysis membrane simulate intestinal absorption. Results show was below 5%, fluorene, anthracene, acenaphthene phenanthrene as most Data suggest no carcinogenic risk PM -bound following health assessment via inhalation-ingestion by benzo(a)pyrene-equivalent concentration hazard indexes. our best knowledge, is first research study estimation -associated